Doctor Ranks Every Overhyped Supplement: Worst To Best

In this video, Dr. Karan Rajan ranks popular supplements from "absolute garbage" to "not terrible" (0:22). He emphasizes that most supplements are based on promises rather than scientific evidence (0:11).

Here's a breakdown of the supplements discussed and their rankings:

Chlorella (F-tier): (0:38)

Marketed as a "detox" agent, but the body's liver and kidneys already handle toxins effectively (0:40).

It's a bioaccumulator, meaning it can absorb harmful metals like lead, cadmium, and arsenic, potentially introducing toxins rather than removing them (1:18).

Claims of "alkalizing blood" are biological fiction and can be harmful (1:39).

5HTP (C-tier): (2:07)

Promoted as a mood booster by increasing serotonin (2:10).

However, taking 5HTP bypasses the body's natural serotonin regulation, leading to most serotonin being produced in the gut, not the brain (2:42).

It has legitimate medical uses under doctor supervision, but self-dosing for mood regulation carries risks (3:11).

Collagen (D-tier): (3:32)

Marketed as a "fountain of youth" for skin and joints (3:34).

The body breaks down collagen into basic amino acids, similar to those found in cheaper foods like eggs or beans (3:41).

Limited evidence suggests marginal benefits for joint support and skin hydration in specific cases, but most studies are small and industry-funded (4:19).

Ashwagandha (B-tier): (5:01)

High-quality studies show that standardized Ashwagandha extracts can lower stress hormone levels and improve sleep (5:07).

It works by calming the body's stress system (HPA axis) (5:22).

Only pharmaceutical-grade standardized extracts deliver these results; random powders are ineffective (5:27).

Ginkgo Biloba (GKO) (D-tier): (5:53)

Marketed as a brain booster for memory and focus (5:55).

A 2012 review found no improvement in memory, focus, or thinking in healthy adults (6:10).

May slightly improve blood flow, which could help with certain types of tinnitus, but effects are inconsistent (6:16). It also thins the blood, posing risks during medical interventions (6:24).

CoQ10 (B-tier): (6:39)

Essential for energy production in cells (6:42).

The body naturally synthesizes CoQ10, so supplementing when healthy is generally useless (6:46).

Medically proven in two scenarios: for muscle issues caused by cholesterol medications and in some cases of heart failure (7:04). Always consult a medical provider (7:29).

Inositol (A-tier for specific conditions, C-tier otherwise): (7:42)

Marketed as an anxiety supplement, but its true strength is in managing metabolic conditions, especially PCOS (7:43).

Studies prove myo-inositol tackles insulin resistance, excess testosterone, ovulation problems, and irregular periods in PCOS patients (7:53).

Evidence for anxiety is weak (8:08). It's a specialist supplement, not a generalist (8:14).

Dr. Karan concludes by stating that the "S-tier" (top tier) is empty because none of these overhyped supplements truly deserve it (8:42). He encourages viewers to check out his other video on supplements that do actually work and to join his newsletter for more science-backed health tips (8:49).

Every Supplement That Actually Works – Explained

This video from Decoded Health explains the essential supplements for people over 40 to maintain health and vitality as their bodies change (0:00). It highlights how various supplements address common age-related concerns like slower recovery, lower energy, weaker bones, and memory decline.

Here is a summary of the supplements discussed in the video:

Vitamin D (0:00) is crucial for bone strength, immune function, and muscle recovery. Deficiency is common in older adults and can be addressed with daily supplementation.

Calcium (0:54) is a vital building block for bones and teeth. Supplementation is often necessary to prevent osteoporosis and related fractures, especially when paired with Vitamin D.

Magnesium (1:47) supports over 300 biochemical reactions in the body, impacting muscle function, sleep, energy production, and heart health.

Vitamin B12 (2:38) is essential for red blood cell production, nerve protection, and energy conversion. Absorption declines with age, making supplementation important for combating fatigue and memory issues.

Omega-3 Fatty Acids (3:25) are crucial for heart and brain health, reducing inflammation and supporting cognitive function.

Coenzyme Q10 (CoQ10) (4:13) is vital for cellular energy production and acts as an antioxidant. Levels decrease with age and statin use, impacting energy levels and heart efficiency.

Collagen (5:02) supports joint flexibility, skin elasticity, and muscle mass. Its production declines after 40, leading to visible signs of aging.

Probiotics (5:43) help maintain a healthy gut microbiome, influencing immunity, nutrient absorption, and mood.

Vitamin K2 (6:30) directs calcium into bones and away from arteries, reducing the risk of fractures and heart disease.

Zinc (7:11) is essential for immune health, wound healing, and the senses of taste and smell. Absorption decreases with age.

Selenium (7:53) acts as a powerful antioxidant, supporting immune function, thyroid health, and cognitive sharpness.

Curcumin (8:35), from turmeric, is a natural anti-inflammatory that helps manage chronic inflammation associated with aging.

Lutein and Zeaxanthin (9:18) are critical for eye health, filtering harmful blue light and protecting against age-related macular degeneration and cataracts.

Choline (10:01) is vital for memory, focus, and liver function, supporting neurotransmitter production.

Green Tea Extract (10:41) provides potent antioxidants that protect cells, support heart health, and regulate metabolism.

Ashwagandha (11:19) is an adaptogenic herb that helps the body cope with stress, improves sleep quality, and boosts mental and physical endurance.

Resveratrol (11:55) is an antioxidant found in red grapes, linked to longevity and cellular repair.

Creatine (12:30) supports muscle mass, strength, and brain performance in older adults.

Iron (13:07) is necessary for oxygen transport in red blood cells. Low iron can lead to fatigue and anemia.

Evening Primrose Oil (EPO) (14:11) supplies gamma-linolenic acid (GLA), which may help with dry skin and hormonal shifts like breast tenderness and hot flashes.

20 Anti Aging Plants That Reverse Aging Instantly

This video discusses 20 plants that can reverse the effects of aging naturally, based on scientific research and traditional uses (0:00). These plants contain powerful compounds that can reprogram cells to behave younger, protect DNA, activate longevity genes, and rebuild cellular structures that maintain youth (0:30).

The video highlights the following plants:

Green Tea (1:26): Contains EGCG antioxidants that protect cells, neutralize free radicals, and lengthen telomeres, which are protective caps on chromosomes associated with biological aging.

Turmeric (3:29): Features curcumin, a compound with potent anti-inflammatory properties that activates longevity genes like SIRT1, protects mitochondria, and helps clear out senescent "zombie" cells.

Ginseng (5:30): An adaptogen that improves mitochondrial function, regulates stress hormones like cortisol, supports insulin sensitivity, and stimulates collagen production for skin elasticity.

Ginkgo Biloba (7:16): Enhances blood flow to the brain and extremities, improving memory and mental clarity, while its antioxidants protect cells from free radical damage.

Aloe Vera (9:01): Contains over 75 active compounds that stimulate fibroblasts to produce collagen and elastin, repair UV damage, and support overall skin health.

Pomegranate (10:58): Triggers mitophagy to clean out dysfunctional mitochondria and generate new ones, improving muscle strength, exercise capacity, and cardiovascular health.

Blueberries (12:44): Rich in anthocyanins that protect against age-related cognitive decline, activate autophagy, reduce inflammation, and improve cardiovascular function.

Peppermint (14:35): Influences cellular markers of aging in stem cells, protects against oxidative stress, improves circulation, and possesses anti-inflammatory properties.

Thyme (16:26): Contains compounds like thymol and carvacrol that target senescent "zombie" cells, reducing inflammation, and protecting against oxidative damage.

Ashwagandha (18:19): An adaptogen that reduces cortisol levels, improves stress resilience, supports hormonal balance, and has neuroprotective effects for brain health.

Amla (Indian Gooseberry) (20:11): High in Vitamin C and polyphenols, essential for collagen synthesis, and protects against oxidative stress, supporting skin, hair, and overall health.

Shatavari (21:59): A rejuvenating herb for women that helps balance hormones, supports tissue hydration, and provides antioxidant and immune-supporting benefits.

Licorice Root (23:44): Contains compounds like glycyrrhizin with anti-inflammatory and antioxidant properties, protecting cells and supporting adrenal function and digestion.

Evening Primrose Oil (25:39): Rich in gamma-linolenic acid (GLA), which improves skin elasticity, moisture, and firmness, and has anti-inflammatory effects throughout the body.

Flax Seed (27:30): Offers omega-3 fatty acids, lignans, and fiber that reduce inflammation, balance hormones, support gut function, and help maintain telomere length.

Olive Leaf and Oil (29:26): Contains oleuropein and other polyphenols that activate longevity genes, protect mitochondria, reduce cellular senescence, and support cardiovascular and brain health.

Soy and Isoflavones (31:17): Features phytoestrogens that stimulate collagen production, improve skin elasticity, support bone health, and aid in maintaining muscle mass.

Kudzu (33:09): The root contains powerful isoflavones and antioxidants that improve circulation, protect blood vessels, stimulate collagen production, and support liver function.

Dark Leafy Greens (35:01): Rich in vitamins, minerals, and phytonutrients like lutein and zeaxanthin that protect eyes, support bone and cardiovascular health, and improve cellular aging markers.

Red Bell Peppers and Colorful Vegetables (36:59): Packed with Vitamin C and carotenoids that stimulate collagen production, reduce wrinkles, protect against UV damage, and provide overall cellular protection.

The video emphasizes that these plants offer a natural and accessible way to combat aging, encouraging consistent use for comprehensive rejuvenation (39:02).

55 Supplement Ingredients Rated Without Mercy!

This video, titled "55 Supplement Ingredients Rated Without Mercy!", features health researcher Ryker Black reviewing 55 popular supplement ingredients, categorizing them into four tiers: A+ (God Tier), A Tier, B Tier (Cautionary Tier), and C Tier (Garbage Tier). The ratings are based on scientific evidence and personal opinion.

Here's a breakdown of some of the key supplements and their ratings:

God Tier (A+) (0:24):

High EPA, DHA, Omega-3 Fish Oil (1:46) for its proven effectiveness.

Astaxanthin (1:59) for its unique properties and fast action.

Taurine (3:25) and Creatine Monohydrate (3:25) due to extensive studies.

Oral Hyaluronic Acid (4:12) and Collagen Peptides (4:14) for skin aging.

Melatonin (4:33) for its benefits beyond sleep, especially for those over 50.

Sirtuin Six Activator (5:29), a proprietary seaweed extract, for its unique activation properties.

Green and Red Superfood Powders (6:11) for their comprehensive nutrient profiles.

NMN (7:13) and NR (7:14) as NAD precursors for longevity.

Spermidine (8:06) for autophagy and hair growth.

Urolithin A (8:16) as a unique mitophagy ingredient.

Calcium Alpha-Ketoglutarate (11:53) for biological age reversal.

GlyNAC (12:31) for boosting glutathione and its longevity benefits.

Sulforaphane (13:08) for its plant-based benefits, including cancer suppression.

A Tier (0:40):

Digestive Enzymes (2:21) and Proteolytic Enzymes (2:24) for improved digestion and immune defense.

Multivitamins and Minerals (2:36) as essential daily supplements.

Vitamin B12 (2:47) for non-meat eaters.

Saw Palmetto (2:52) for men's DHT levels.

Vitamin D3 (3:51), K2 (3:51), and Magnesium (3:52) for bone health.

Lycopene (4:43) (specifically Lycomato) for prostate health.

Green Tea Extract (6:30) (specifically EGCG) for health benefits and fat loss.

TMG (7:34) and Apigenin (7:34) for supporting NMN and NR.

Protein Powder (8:23) for meeting daily protein requirements.

CoQ10 (8:45) and PQQ (8:45) for mitochondrial support.

DHEA (8:52) for hormone support in later life.

Berberine (9:55) for blood sugar control and weight loss.

Curcumin (10:03) for osteoporosis pain relief.

Alpha-Lipoic Acid (12:04) for diabetic neuropathy and antioxidant benefits.

Fisetin (12:21) for its senolytic benefits.

L-Carnosine (12:52) and Beta-Alanine (12:54) for boosting muscle carnosine.

Quercetin (13:29) for blood sugar control and allergy suppression.

B Tier (Cautionary Tier) (0:57):

Resveratrol (1:05, 3:34) due to dose-dependent issues.

Branched-Chain Amino Acids (BCAAs) (4:53) considered pointless for most individuals who consume enough protein.

Selenium (5:12) due to its narrow therapeutic range and potential danger in high doses.

Glucosamine (7:45) and Chondroitin (7:46) due to mixed study results and anecdotal effectiveness.

Liposomal Supplements (10:45) due to claims of massively increased absorption rates being unsupported.

Milk Thistle Extract (11:18) for its anecdotal rather than science-based evidence of efficacy.

C Tier (Garbage Tier) (1:21):

Colloidal Silver (2:07) due to ineffectiveness, toxicity, and potential side effects.

St. John's Wort (3:09) for its lack of proven benefits and potential dangerous drug interactions.

Raspberry Ketones (6:05) as a popular scam weight loss product.

Low-Dose All-in-One Supplements (6:41) with insufficient active ingredient dosages.

Ginkgo Biloba (6:59) due to its classification as a carcinogen and numerous drug interactions.

Iron Supplements (9:00) for healthy adults, unless diagnosed with anemia.

Yohimbe (9:29) for its dangerous drug interactions and minimal proven benefits.

Calcium Supplements (10:21) unless medically diagnosed as necessary, due to potential harm from excessive intake.

Bitter Orange (11:34) for its link to heart attacks and strokes with minimal weight loss evidence.

The video also provides discount codes for iHerb.com and DoNotAge.org (1:35).

Dr. Matt Ranks Longevity Supplements: The Winners and Total Scams

In this video, Dr. Matt Kaeberlein ranks 13 popular longevity supplements based on scientific evidence, categorizing them into "strong," "good," "promising," "overhyped," or "avoid" (1:41). He emphasizes that the supplement industry is often filled with hype and questionable science (0:00).

Here's a breakdown of his rankings and reasoning:

Fucoidan (2:27): Ranked as "avoid" due to extremely weak longevity data and concerns about purity and contamination from sourcing. The effective dose for humans, extrapolated from mouse studies, would be an unfeasible 50 grams per day (3:51).

Fisetin (8:04): Placed in the "overhyped" category. While a putative senolytic, mouse lifespan effects haven't been reproducible, and human clinical trial data is still early and weak (8:14).

Lithium Orotate (8:54): Categorized as "strong," though Dr. Matt admits he might have been overly enthusiastic. Strong epidemiological data links lithium in drinking water to lower mortality and dementia risk, supported by preclinical animal data (9:19).

Resveratrol (11:51): Firmly in the "avoid" category, labeled as the "most overhyped longevity intervention ever." The initial lifespan extension reports in yeast were found to be incorrect, and meta-analyses show no effect on lifespan (12:41).

Creatine (13:24): Ranked as "strong." Dr. Matt highlights solid evidence that 3-5 grams per day combined with resistance training significantly improves body composition. It also shows protective effects on the brain (13:20).

CoQ10 (14:58): Placed in the "overhyped" category. While an essential mitochondrial co-factor and useful for certain heart conditions, there's no strong evidence that supplementation meaningfully affects aging or longevity in healthy people (15:37).

SS Peptides (SS-31/Elamipretide) (15:53): Categorized as "avoid" for healthy individuals, as it's a prescription medication, not a supplement. Despite localizing to mitochondria and potentially improving some functions, there's no strong evidence for general longevity benefits, and concerns exist about purity, dosing, and long-term safety in humans (16:11).

Proprietary "Anti-Aging" Blends (24:09): Strongly advised to "avoid." Dr. Matt states that anything marketed as "anti-aging" is misleading, and blends often lack transparency regarding ingredients, purity, and consistent activity across batches (23:51).

NAD+ Precursors (24:55): Placed in both "promising" and "overhyped." While boosting NAD might be beneficial in some contexts, the idea of universal age-related decline is a myth, and preclinical data is mixed regarding reproducibility and lifespan effects. Human clinical trials are early, and costs can be high (25:04).

Omega-3 (27:17): Ranked as "strong." Dr. Matt recommends measuring omega-3 levels and supplementing to reach an optimal range (greater than 8% omega index, EPA + DHA) due to extensive epidemiological data and plausible biochemical mechanisms for reducing mortality and improving heart and brain health (27:26).

Vitamin D (28:47): Also ranked as "strong." Similar to omega-3, Dr. Matt advises measuring levels and supplementing to achieve an optimal range (e.g., 50-60 nanograms per deciliter), noting that individual needs vary and it takes time to reach steady-state levels (28:27).

Fatty 15 (Pentadecanoic Acid) (29:24): Considered "overhyped" but potentially "promising." Dr. Matt views it more as a marketing phenomenon due to a lack of human clinical trials on supplementation benefits and essentially non-existent animal data for longevity (29:47).

Urolithin A (31:01): Placed in the "good" and "promising" categories. It's thought to be a mitophagy activator, with good animal data showing lifespan extension in worms and healthspan benefits in mice. Early human trials show some positive effects, though the overall impact is likely small compared to interventions like exercise (31:21).

In his final ranking (32:31), Dr. Matt positions Creatine as the top supplement due to its proven benefits and safety, followed closely by Omega-3 and Vitamin D. Lithium Orotate comes next, with Urolithin A and NAD+ precursors following. CoQ10, Resveratrol, Fatty 15, and Fisetin are lower on the list, while Proprietary Anti-Aging Blends, Fucoidan, and SS Peptides are at the bottom, primarily due to safety concerns, lack of data, or misleading marketing (34:41).

These 7 Brain Supplements Will Define 2026 Winners

This video discusses seven nootropic supplements that can enhance brain function and help individuals thrive in 2026.

Here's a breakdown of the key supplements and their benefits:

Lion's Mane Mushroom (1:46)

Stimulates nerve growth factor (NGF), promoting neuron regeneration and combating cognitive decline.

Recommended dosage: 500-2,000 mg/day, ensuring the extract includes both fruiting body and mycelium.

L-Theanine (3:22)

An amino acid from green tea that promotes calmness and alertness without jitters.

Boosts alpha and theta brain waves, increasing dopamine, GABA, and serotonin.

Pairs well with caffeine (2:1 ratio of L-Theanine to caffeine) to smooth out its effects.

Recommended dosage: 150-200 mg as needed during the day.

Magnesium L-Threonate (4:38)

A form of magnesium that effectively crosses the blood-brain barrier.

Regulates ion channels for proper neuron communication, improving cognitive performance.

Addresses issues like anxiety, depression, brain fog, and poor memory linked to magnesium deficiency.

Recommended dosage: 1,000 mg before bed for improved sleep.

Citicoline (CDP-Choline) (5:58)

A powerful nootropic for memory and cognitive performance.

Provides choline to produce acetylcholine (for learning and memory) and boosts phosphatidylcholine for brain cell integrity.

Recommended dosage: 250-300 mg twice a day (morning and early afternoon).

Bacopa Monnieri (7:33)

An Ayurvedic herb that enhances learning and memory by repairing damaged neurons and promoting new nerve growth.

Improves memory retention, reduces anxiety, and enhances information processing speed.

Effects are typically seen after a few weeks of consistent use.

Recommended dosage: Up to 750 mg/day of a standardized extract (20% bacosides), taken with a meal.

Rhodiola Rosea (8:54)

An adaptogen that helps the body cope with physical, chemical, and environmental stress.

Regulates cortisol levels and supports dopamine and serotonin production.

Effective for chronic stress, burnout, and mental fatigue.

Recommended dosage: 150-200 mg/day of a standardized extract (3% rosins, 1% salidroside), taken in the morning or early afternoon.

L-Tyrosine (10:40)

An amino acid precursor to dopamine, norepinephrine, and epinephrine, crucial for motivation, focus, learning, and stress response.

Replenishes neurotransmitters during high-stress situations.

Recommended dosage: 500 mg two or three times per day.

The video also offers options for building a nootropic stack:

Building a personalized stack (12:12) by buying individual supplements.

Using a pre-formulated nootropic stack (12:23) like Mind Lab Pro, which combines many of these ingredients.

Personal consultations (12:58) for tailored advice on building a stack.

Joining their YouTube membership program (13:35) for ongoing support and feedback.

Every Life Changing Vitamin & Mineral You Should Probably Be Taking Explained

This video explains the importance of various vitamins and minerals for your body's optimal functioning. It highlights how deficiencies in these essential nutrients can lead to common issues like fatigue, brain fog, and poor sleep, and how proper supplementation can alleviate these problems.

Here's a breakdown of the key vitamins and minerals discussed:

Vitamin D (0:00-1:37): Functions like a hormone, regulating cell communication, growth, and immune response. Deficiency can cause depression, hair loss, and fatigue. It's often paired with Vitamin K2 (1:09) to direct calcium to bones.

Vitamin B12 (1:37-2:58): Crucial for rebuilding the nervous system, DNA repair, and neurotransmitter production. It helps eliminate brain fog, restore energy, and sharpen memory. Vegans and older adults are at higher risk of deficiency.

Vitamin B1 (Thiamine) (2:58-4:09): Essential for metabolizing alcohol and converting glucose into cellular energy. It can reduce anxiety, improve stress tolerance, and treat restless leg syndrome.

Zinc (4:09-5:17): Boosts the immune system by producing T-cells that fight viruses and helps regulate the immune response to prevent inflammation. It can also heal stomach ulcers.

Selenium (5:17-6:36): Converts inactive thyroid hormone (T4) into the active form (T3), regulating metabolism and energy. It helps reduce symptoms of Hashimoto's thyroiditis and acts as a powerful antioxidant.

Vitamin C (6:36-8:00): A co-factor for collagen production, vital for skin, blood vessels, and gums. It also strengthens the immune system and acts as an antioxidant. Ester C (7:26) is a buffered form that is easier on the stomach.

Biotin (8:00-9:11): Activates enzymes that produce keratin, essential for healthy hair, nails, and skin. It works best as part of a B complex (8:56).

Niacin (9:11-10:30): Can significantly reduce bad cholesterol (LDL) and raise good cholesterol (HDL). It also boosts energy, improves skin health, and enhances circulation. High doses can cause a temporary "flush."

Magnesium Glycinate (10:30-12:04): Regulates GABA, a neurotransmitter that calms brain activity, promoting better sleep. It also controls muscle contractions, stabilizes heart rhythm, and can help with migraines and anxiety.

Potassium (12:04-13:21): Maintains electrical gradients across cell membranes, vital for muscle contraction, nerve signaling, and heartbeat regulation. It helps reduce muscle cramps and may lower blood pressure.

Iron (13:21-15:08): Essential for building hemoglobin, which delivers oxygen to cells. Deficiency can lead to anemia, causing deep exhaustion. Pairing it with Vitamin C (14:21) boosts absorption.

The video emphasizes that proper supplementation, especially with reputable and third-party tested brands, can make a significant difference in overall well-being.